Publication: Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort
Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort
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Church, R. J., Kullak-Ublick, G. A., Aubrecht, J., & et al. (2019). Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort. Hepatology, 69, 760–773. https://doi.org/10.1002/hep.29802
Abstract
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Abstract
Current blood biomarkers are suboptimal in detecting drug-induced liver injury (DILI) and predicting its outcome. We sought to characterize the natural variabilty and performance characteristics of fourteen promising DILI biomarker candidates. Serum or plasma from multiple cohorts of healthy volunteers (n=192 and =81), subjects who safely took potentially hepatotoxic drugs without adverse effects (n=55 and =92) and DILI patients (n=98, =28, and =143) were assayed for microRNA-122 (miR-122), glutamate dehydrogenase (GLDH), total kerati
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- Church, Rachel J
- Kullak-Ublick, Gerd A
- Aubrecht, Jiri
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Citations
Church, R. J., Kullak-Ublick, G. A., Aubrecht, J., & et al. (2019). Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort. Hepatology, 69, 760–773. https://doi.org/10.1002/hep.29802
