Publication: PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice
Date
Date
Date
2021
Journal Article
Published version
Abstract
Abstract
Abstract
While Epstein-Barr virus (EBV) establishes a life-long latent infection in apparently healthy human immunocompetent hosts, immunodeficient individuals are at particular risk to develop lymphoproliferative B-cell malignancies caused by EBV. A key EBV protein is the transcription factor EBV nuclear antigen 2 (EBNA2), which initiates B-cell proliferation. Here, we combine biochemical, cellular, and in vivo experiments demonstrating that the mitotic polo-like kinase 1 (PLK1) binds to EBNA2, phosphorylates its transactivation domain, and t
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30 since deposited on 2022-01-28
Acq. date: 2025-11-13
Views
68 since deposited on 2022-01-28
Acq. date: 2025-11-13
Additional indexing
Creators (Authors)
- Zhang, Xiang
- Schuhmachers, Patrick
- Mourão, André
- Murer, Anita
- Münz, Christian
Volume
Volume
Volume
22
Number
Number
Number
12
Page range/Item number
Page range/Item number
Page range/Item number
e53007
Item Type
Item Type
Item Type
Journal Article
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
English
Publication date
Publication date
Publication date
2021-12-06
Date available
Date available
Date available
2022-01-28
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
1469-221X
OA Status
OA Status
OA Status
Hybrid
Free Access at
Free Access at
Free Access at
Pubmed ID
Publisher DOI
Metrics
Downloads
30 since deposited on 2022-01-28
Acq. date: 2025-11-13
Views
68 since deposited on 2022-01-28
Acq. date: 2025-11-13
Hybrid Open Access
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