Publication: Deletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCC
Deletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCC
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Schnoz, C., Moser, S., Kratschmar, D. V., Odermatt, A., Loffing-Cueni, D., & Loffing, J. (2021). Deletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCC. Pflügers Archiv : European Journal of Physiology, 473(1), 79–93. https://doi.org/10.1007/s00424-020-02491-1
Abstract
Abstract
Abstract
The renal distal convoluted tubule (DCT) is critical for the fine-tuning of urinary ion excretion and the control of blood pressure. Ion transport along the DCT is tightly controlled by posttranscriptional mechanisms including a complex interplay of kinases, phosphatases, and ubiquitin ligases. Previous work identified the transcription factor Prox-1 as a gene significantly enriched in the DCT of adult mice. To test if Prox-1 contributes to the transcriptional regulation of DCT function and structure, we developed a novel mouse model
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Creators (Authors)
- Schnoz, Christina
- Moser, Sandra
- Kratschmar, Denise V
- Odermatt, Alex
- Loffing-Cueni, Dominique
- Loffing, Johannes
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Citations
Schnoz, C., Moser, S., Kratschmar, D. V., Odermatt, A., Loffing-Cueni, D., & Loffing, J. (2021). Deletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCC. Pflügers Archiv : European Journal of Physiology, 473(1), 79–93. https://doi.org/10.1007/s00424-020-02491-1
