The adaptor protein c-Cbl-associated protein (CAP) limits pro-inflammatory cytokine expression by inhibiting the NF-κB pathway

Vdovenko, Daria; Bachmann, Marta; Wijnen, Winandus J; Hottiger, Michael O; Eriksson, Urs; Valaperti, Alan

doi:10.1016/j.intimp.2020.106822

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Vdovenko, D., Bachmann, M., Wijnen, W. J., Hottiger, M. O., Eriksson, U., & Valaperti, A. (2020). The adaptor protein c-Cbl-associated protein (CAP) limits pro-inflammatory cytokine expression by inhibiting the NF-κB pathway. International Immunopharmacology, 87, 106822. https://doi.org/10.1016/j.intimp.2020.106822

Abstract

C-Cbl-associated protein (CAP), also known as Sorbin and SH3 domain-containing protein 1 (Sorbs1) or ponsin, an adaptor protein of the insulin-signalling pathway, mediates anti-viral and anti-cytotoxic protection in acute viral heart disease. In the present study we describe a novel protective immuno-modulatory function of CAP in inflammation.

Among the three members of the Sorbs family of adapter molecules, which include CAP (Sorbs1), ArgBP2 (Sorbs2), and Vinexin (Sorbs3), CAP consistently down-regulated the expression of pro-inflam