Differential temporal profile of lowered blood glucose levels (3.5 to 6.5 mmol/l versus 5 to 8 mmol/l) in patients with severe traumatic brain injury

Meier, R; Béchir, M; Ludwig, S; Sommerfeld, J; Keel, M; Steiger, P; Stocker, R; Stover, J F

doi:10.1186/cc6974

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Meier, R., Béchir, M., Ludwig, S., Sommerfeld, J., Keel, M., Steiger, P., Stocker, R., & Stover, J. F. (2008). Differential temporal profile of lowered blood glucose levels (3.5 to 6.5 mmol/l versus 5 to 8 mmol/l) in patients with severe traumatic brain injury. Critical Care, 12, R98. https://doi.org/10.1186/cc6974

Abstract

INTRODUCTION: Hyperglycaemia is detrimental, but maintaining low blood glucose levels within tight limits is controversial in patients with severe traumatic brain injury, because decreased blood glucose levels can induce and aggravate underlying brain injury. METHODS: In 228 propensity matched patients (age, sex and injury severity) treated in our intensive care unit (ICU) from 2000 to 2004, we retrospectively evaluated the influence of different predefined blood glucose targets (3.5 to 6.5 versus 5 to 8 mmol/l) on frequency of hypogl