Fractional Anisotropy in Selected, Motor-Related White Matter Tracts and Its Cross-Sectional and Longitudinal Associations With Motor Function in Healthy Older Adults

Oschwald, Jessica; Mérillat, Susan; Jäncke, Lutz; Seidler, Rachael D

doi:10.3389/fnhum.2021.621263

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Oschwald, J., Mérillat, S., Jäncke, L., & Seidler, R. D. (2021). Fractional Anisotropy in Selected, Motor-Related White Matter Tracts and Its Cross-Sectional and Longitudinal Associations With Motor Function in Healthy Older Adults. Frontiers in Human Neuroscience, 15, 621263. https://doi.org/10.3389/fnhum.2021.621263

Abstract

Background: While it is well-known that deficits in motor performance and brain structural connectivity occur in the course of healthy aging, it is still unclear if and how these changes are related to each other. While some cross-sectional studies suggest that white matter (WM) microstructure is positively associated with motor function in healthy older adults, more evidence is needed. Moreover, longitudinal data is required to estimate whether similar associations can be found between trajectories of change in WM microstructure and