Publication: First characterization of human amniotic fluid stem cell extracellular vesicles as a powerful paracrine tool endowed with regenerative potential
First characterization of human amniotic fluid stem cell extracellular vesicles as a powerful paracrine tool endowed with regenerative potential
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Balbi, C., Piccoli, M., Barile, L., Papait, A., Armirotti, A., Principi, E., Reverberi, D., Pascucci, L., Becherini, P., Varesio, L., Mogni, M., Coviello, D., Bandiera, T., Pozzobon, M., Cancedda, R., & Bollini, S. (2017). First characterization of human amniotic fluid stem cell extracellular vesicles as a powerful paracrine tool endowed with regenerative potential. Stem Cells Translational Medicine, 6, 1340–1355. https://doi.org/10.1002/sctm.16-0297
Abstract
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Abstract
Human amniotic fluid stem cells (hAFS) have shown a distinct secretory profile and significant regenerative potential in several preclinical models of disease. Nevertheless, little is known about the detailed characterization of their secretome. Herein we show for the first time that hAFS actively release extracellular vesicles (EV) endowed with significant paracrine potential and regenerative effect. c-KIT+ hAFS were isolated from leftover samples of amniotic fluid from prenatal screening and stimulated to enhance EV release (24 hour
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- Balbi, Carolina
- Piccoli, Martina
- Barile, Lucio
- Papait, Andrea
- Armirotti, Andrea
- Principi, Elisa
- Reverberi, Daniele
- Pascucci, Luisa
- Becherini, Pamela
- Varesio, Luigi
- Mogni, Massimo
- Coviello, Domenico
- Bandiera, Tiziano
- Pozzobon, Michela
- Cancedda, Ranieri
- Bollini, Sveva
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Balbi, C., Piccoli, M., Barile, L., Papait, A., Armirotti, A., Principi, E., Reverberi, D., Pascucci, L., Becherini, P., Varesio, L., Mogni, M., Coviello, D., Bandiera, T., Pozzobon, M., Cancedda, R., & Bollini, S. (2017). First characterization of human amniotic fluid stem cell extracellular vesicles as a powerful paracrine tool endowed with regenerative potential. Stem Cells Translational Medicine, 6, 1340–1355. https://doi.org/10.1002/sctm.16-0297
