Publication: Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model
Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model
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Keller, N., Andreoni, F., Reiber, C., Luethi-Schaller, H., Schuepbach, R. A., Moch, H., Marques Maggio, E., & Zinkernagel, A. S. (2018). Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model. American Journal of Pathology, 188(7), 1517–1523. https://doi.org/10.1016/j.ajpath.2018.03.009
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Abstract
Streptococcal necrotizing fasciitis (NF) causes high morbidity and mortality despite state-of-the-art therapy. Low incidence and rapid disease progression, necessitating immediate initiation of therapy, have proven challenging aspects for setting up prospective randomized trials. This has resulted in little therapeutic progress over the past decade. The validation of reliable murine NF models to study both pathogenesis and optimized therapeutic regimens of streptococcal NF are thus essential. In this study, we characterized a murine N
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- Keller, Nadia
- Andreoni, Federica
- Reiber, Claudine
- Luethi-Schaller, Helga
- Schuepbach, Reto Andreas
- Moch, Holger
- Marques Maggio, Ewerton
- Zinkernagel, Annelies Sophie
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Keller, N., Andreoni, F., Reiber, C., Luethi-Schaller, H., Schuepbach, R. A., Moch, H., Marques Maggio, E., & Zinkernagel, A. S. (2018). Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model. American Journal of Pathology, 188(7), 1517–1523. https://doi.org/10.1016/j.ajpath.2018.03.009