Publication: Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study
Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study
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Dobrinas, M., Crettol, S., Oneda, B., Lahyani, R., Rotger, M., Choong, E., Lubomirov, R., Csajka, C., & Eap, C. B. (2013). Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study. Pharmacogenetics and Genomics, 23, 84–93. https://doi.org/10.1097/FPC.0b013e32835cb2e2
Abstract
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Abstract
BACKGROUND: (S)-Methadone, metabolized mainly by CYP2B6, shows a wide interindividual variability in its pharmacokinetics and pharmacodynamics. METHODS: Resequencing of the CYP2B6 gene was performed in 12 and 35 selected individuals with high (S)-methadone plasma exposure and low (S)-methadone plasma exposure, respectively, from a previously described cohort of 276 patients undergoing methadone maintenance treatment. Selected genetic polymorphisms were then analyzed in the complete cohort. RESULTS: The rs35303484 (*11; c136A>G; M46V)
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- Dobrinas, Maria
- Crettol, Séverine
- Oneda, Beatrice
- Lahyani, Rachel
- Rotger, Margalida
- Choong, Eva
- Lubomirov, Rubin
- Csajka, Chantal
- Eap, Chin B
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Dobrinas, M., Crettol, S., Oneda, B., Lahyani, R., Rotger, M., Choong, E., Lubomirov, R., Csajka, C., & Eap, C. B. (2013). Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study. Pharmacogenetics and Genomics, 23, 84–93. https://doi.org/10.1097/FPC.0b013e32835cb2e2
