Publication: Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability
Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability
Date
Date
Date
Citations
Karve, S., Dasmeh, P., Zheng, J., & Wagner, A. (2022). Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability. Nature Ecology and Evolution, 6(8), 1155–1164. https://doi.org/10.1038/s41559-022-01797-w
Abstract
Abstract
Abstract
Protein abundance affects the evolution of protein genotypes, but we do not know how it affects the evolution of protein phenotypes. Here we investigate the role of protein abundance in the evolvability of green fluorescent protein (GFP) towards the novel phenotype of cyan fluorescence. We evolve GFP in E. coli through multiple cycles of mutation and selection and show that low GFP expression facilitates the evolution of cyan fluorescence. A computational model whose predictions we test experimentally helps explain why: lowly expresse
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Karve, Shraddha
- Dasmeh, Pouria
- Zheng, Jia
- Wagner, Andreas
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Karve, S., Dasmeh, P., Zheng, J., & Wagner, A. (2022). Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability. Nature Ecology and Evolution, 6(8), 1155–1164. https://doi.org/10.1038/s41559-022-01797-w
