Publication: Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters
Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters
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Brandenberg, O. F., Magnus, C., Rusert, P., Günthard, H. F., Regoes, R. R., & Trkola, A. (2017). Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters. PLoS Pathogens, 13(5), e1006313. https://doi.org/10.1371/journal.ppat.1006313
Abstract
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Abstract
The potential of broadly neutralizing antibodies targeting the HIV-1 envelope trimer to prevent HIV-1 transmission has opened new avenues for therapies and vaccines. However, their implementation remains challenging and would profit from a deepened mechanistic understanding of HIV-antibody interactions and the mucosal transmission process. In this study we experimentally determined stoichiometric parameters of the HIV-1 trimer-antibody interaction, confirming that binding of one antibody is sufficient for trimer neutralization. This d
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- Brandenberg, Oliver F
- Magnus, Carsten
- Rusert, Peter
- Günthard, Huldrych F
- Regoes, Roland Robert
- Trkola, Alexandra
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Brandenberg, O. F., Magnus, C., Rusert, P., Günthard, H. F., Regoes, R. R., & Trkola, A. (2017). Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters. PLoS Pathogens, 13(5), e1006313. https://doi.org/10.1371/journal.ppat.1006313
