Publication: Twin study dissects CXCR3$^{+}$ memory B cells as non-heritable feature in multiple sclerosis
Twin study dissects CXCR3$^{+}$ memory B cells as non-heritable feature in multiple sclerosis
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Ingelfinger, F., Kuiper, K. L., Ulutekin, C., Rindlisbacher, L., Mundt, S., Gerdes, L. A., Smolders, J., van Luijn, M. M., & Becher, B. (2024). Twin study dissects CXCR3$^{+}$ memory B cells as non-heritable feature in multiple sclerosis. Med, 5(4), 368-373.e3. https://doi.org/10.1016/j.medj.2024.02.013
Abstract
Abstract
Abstract
BACKGROUND
In multiple sclerosis (MS), B cells are considered main triggers of the disease, likely as the result of complex interaction between genetic and environmental risk factors. Studies on monozygotic twins discordant for MS offer a unique way to reduce this complexity and reveal discrepant subsets.
METHODS
In this study, we analyzed B cell subsets in blood samples of monozygotic twins with and without MS using publicly available data. We verified functional characteristics by exploring the role of therapy and performed separ
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Creators (Authors)
- Ingelfinger, Florian
- Kuiper, Kirsten L
- Ulutekin, Can
- Rindlisbacher, Lukas
- Mundt, Sarah
- Gerdes, Lisa Ann
- Smolders, Joost
- van Luijn, Marvin M
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Ingelfinger, F., Kuiper, K. L., Ulutekin, C., Rindlisbacher, L., Mundt, S., Gerdes, L. A., Smolders, J., van Luijn, M. M., & Becher, B. (2024). Twin study dissects CXCR3$^{+}$ memory B cells as non-heritable feature in multiple sclerosis. Med, 5(4), 368-373.e3. https://doi.org/10.1016/j.medj.2024.02.013
