Publication: The Hidden Cell-to-Cell Trail of α-Synuclein Aggregates
The Hidden Cell-to-Cell Trail of α-Synuclein Aggregates
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Neupane, S., De Cecco, E., & Aguzzi, A. (2023). The Hidden Cell-to-Cell Trail of α-Synuclein Aggregates. Journal of Molecular Biology, 435(12), 167930. https://doi.org/10.1016/j.jmb.2022.167930
Abstract
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Abstract
The progressive accumulation of insoluble aggregates of the presynaptic protein alpha-synuclein (α-Syn) is a hallmark of neurodegenerative disorders including Parkinson's disease (PD), Multiple System Atrophy, and Dementia with Lewy Bodies, commonly referred to as synucleinopathies. Despite considerable progress on the structural biology of these aggregates, the molecular mechanisms mediating their cell-to-cell transmission, propagation, and neurotoxicity remain only partially understood. Numerous studies have highlighted the stereoty
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- Neupane, Sandesh
- De Cecco, Elena
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Neupane, S., De Cecco, E., & Aguzzi, A. (2023). The Hidden Cell-to-Cell Trail of α-Synuclein Aggregates. Journal of Molecular Biology, 435(12), 167930. https://doi.org/10.1016/j.jmb.2022.167930
