Prolyl isomerase PIN1 regulates DNA double-strand break repair by Counteracting DNA end resection

Steger, Martin; Murina, Olga; Hühn, Daniela; Ferretti, Lorenza P; Walser, Reto; Hänggi, Kay; Lafranchi, Lorenzo; Neugebauer, Christine; Paliwal, Shreya; Janscak, Pavel; Gerrits, Bertran; Del Sal, Giannino; Zerbe, Oliver; Sartori, Alessandro A

doi:10.5167/uzh-78112

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Steger, M., Murina, O., Hühn, D., Ferretti, L. P., Walser, R., Hänggi, K., Lafranchi, L., Neugebauer, C., Paliwal, S., Janscak, P., Gerrits, B., Del Sal, G., Zerbe, O., & Sartori, A. A. (2013). Prolyl isomerase PIN1 regulates DNA double-strand break repair by Counteracting DNA end resection. Molecular Cell, 50, 333–343. https://doi.org/10.1016/j.molcel.2013.03.023

Abstract

The regulation of DNA double-strand break (DSB) repair by phosphorylation-dependent signaling pathways is crucial for the maintenance of genome stability; however, remarkably little is known about the molecular mechanisms by which phosphorylation controls DSB repair. Here, we show that PIN1, a phosphorylation-specific prolyl isomerase, interacts with key DSB repair factors and affects the relative contributions of homologous recombination (HR) and nonhomologous end-joining (NHEJ) to DSB repair. We find that PIN1-deficient cells displa