Publication: Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney
Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney
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Zaïr, Z. M., Eloranta, J. J., Stieger, B., & Kullak-Ublick, G. A. (2008). Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. Pharmacogenomics, 9, 597–624. https://doi.org/10.2217/14622416.9.5.597
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The role of carrier-mediated transport in determining the pharmacokinetics of drugs has become increasingly evident with the discovery of genetic variants that affect expression and/or function of a given drug transporter. Drug transporters are expressed at numerous epithelial barriers, such as intestinal epithelial cells, hepatocytes, renal tubular cells and at the blood-brain barrier. Several recent studies have associated alterations in substrate uptake with the presence of SNPs. Here, we summarize the current knowledge on the func
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- Zaïr, Z M
- Eloranta, J J
- Stieger, B
- Kullak-Ublick, G A
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Zaïr, Z. M., Eloranta, J. J., Stieger, B., & Kullak-Ublick, G. A. (2008). Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. Pharmacogenomics, 9, 597–624. https://doi.org/10.2217/14622416.9.5.597
