Publication: Multiple toxin production in the cyanobacterium microcystis: isolation of the toxic protease inhibitor cyanopeptolin 1020
Date
Date
Date
2010
Journal Article
Published version
Abstract
Abstract
Abstract
The isolation and structure of cyanopeptolin 1020 (hexanoic acid-Glu-N[-O-Thr-Arg-Ahp-Phe-N-Me-Tyr-Val-]) from a Microcystis strain is reported. Very potent picomolar trypsin inhibition (IC(50) = 670 pM) and low nanomolar values against human kallikrein (4.5 nM) and factor XIa (3.9 nM) have been determined for cyanopeptolin 1020. For plasmin and chymotrypsin, low micromolar concentrations were necessary for 50% inhibition. Cyanopeptolin 1020 was found to be toxic against the freshwater crustacean Thamnocephalus platyurus (LC(50) = 8.8
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Downloads
523 since deposited on 2011-02-25
Acq. date: 2025-11-12
Views
189 since deposited on 2011-02-25
Acq. date: 2025-11-12
Additional indexing
Creators (Authors)
- Gademann, K
- Portmann, C
- Blom, J F
- Zeder, M
- Jüttner, F
Volume
Volume
Volume
73
Number
Number
Number
5
Page range/Item number
Page range/Item number
Page range/Item number
980
Page end
Page end
Page end
984
Item Type
Item Type
Item Type
Journal Article
In collections
Language
Language
Language
English
Publication date
Publication date
Publication date
2010
Date available
Date available
Date available
2011-02-25
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
0163-3864
Additional Information
Additional Information
Additional Information
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright © American Chemical Society after peer review and technical editing by the publisher.
OA Status
OA Status
OA Status
Green
Publisher DOI
Metrics
Downloads
523 since deposited on 2011-02-25
Acq. date: 2025-11-12
Views
189 since deposited on 2011-02-25
Acq. date: 2025-11-12
Green Open Access
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