Publication: A Versatile “Synthesis Tag” (SynTag) for the Chemical Synthesis of Aggregating Peptides and Proteins
A Versatile “Synthesis Tag” (SynTag) for the Chemical Synthesis of Aggregating Peptides and Proteins
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Bürgisser, H., Williams, E. T., Jeandin, A., Lescure, R., Premanand, A., Wang, S., & Hartrampf, N. (2024). A Versatile “Synthesis Tag” (SynTag) for the Chemical Synthesis of Aggregating Peptides and Proteins. Journal of the American Chemical Society, 146, 34887–34899. https://doi.org/10.1021/jacs.4c14247
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Abstract
Solid-phase peptide synthesis (SPPS) and native chemical ligation (NCL) are powerful methods for obtaining peptides and proteins that are otherwise inaccessible. Nonetheless, numerous sequences are difficult to prepare via SPPS, and cleaved peptides often have low aqueous solubility. To address these challenges, we developed a “Synthesis Tag” consisting of six arginines connected to the target sequence via a cleavable MeDbz linker. “SynTag” effectively improves batch- and flow-SPPS of “difficult sequences”, enhances the solubility of
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- Bürgisser, Héloïse
- Williams, Elyse T
- Jeandin, Aliénor
- Lescure, Robin
- Premanand, Adhvitha
- Wang, Songlin
- Hartrampf, Nina
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Bürgisser, H., Williams, E. T., Jeandin, A., Lescure, R., Premanand, A., Wang, S., & Hartrampf, N. (2024). A Versatile “Synthesis Tag” (SynTag) for the Chemical Synthesis of Aggregating Peptides and Proteins. Journal of the American Chemical Society, 146, 34887–34899. https://doi.org/10.1021/jacs.4c14247
