Socioeconomic inequalities in molecular risk for chronic diseases observed in young adulthood

Shanahan, Michael J; Cole, Steven W; Ravi, Sudharshan; Chumbley, Justin; Xu, Wenjia; Potente, Cecilia; Levitt, Brandt; Bodelet, Julien; Aiello, Allison; Gaydosh, Lauren; Harris, Kathleen Mullan

doi:10.1073/pnas.2103088119

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Shanahan, M. J., Cole, S. W., Ravi, S., Chumbley, J., Xu, W., Potente, C., Levitt, B., Bodelet, J., Aiello, A., Gaydosh, L., & Harris, K. M. (2022). Socioeconomic inequalities in molecular risk for chronic diseases observed in young adulthood. Proceedings of the National Academy of Sciences of the United States of America, 119(43), e2103088119. https://doi.org/10.1073/pnas.2103088119

Abstract

Many common chronic diseases of aging are negatively associated with socioeconomic status (SES). This study examines whether inequalities can already be observed in the molecular underpinnings of such diseases in the 30s, before many of them become prevalent. Data come from the National Longitudinal Study of Adolescent to Adult Health (Add Health), a large, nationally representative sample of US subjects who were followed for over two decades beginning in adolescence. We now have transcriptomic data (mRNA-seq) from a random subset of