Effect of platelet-derived growth factor-BB on tissue integration of cross-linked and non-cross-linked collagen matrices in a rat ectopic model

Thoma, Daniel S; Nänni, Nadja; Benic, Goran I; Weber, Franz E; Hämmerle, Christoph H F; Jung, Ronald E

doi:10.1111/clr.12496

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Thoma, D. S., Nänni, N., Benic, G. I., Weber, F. E., Hämmerle, C. H. F., & Jung, R. E. (2015). Effect of platelet-derived growth factor-BB on tissue integration of cross-linked and non-cross-linked collagen matrices in a rat ectopic model. Clinical Oral Implants Research, 26(3), 263–270. https://doi.org/10.1111/clr.12496

Abstract

AIM: To test whether or not the network structure and the addition of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to a chemically cross-linked collagen matrix (CCM)- and a non-cross-linked collagen matrix (NCCM)-influenced tissue integration, angiogenesis, and matrix degradation. MATERIALS AND METHODS: Four treatment modalities were randomly assigned to four unconnected pouches in the back of 50 rats: (i) CCM-S (soaked in saline), (ii) CCM-P (plus rhPDGF-BB), (iii) NCCM-S (soaked in saline), and (iv) NCCM-P (plus r