Publication: IL-6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic nucleus neurons
IL-6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic nucleus neurons
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Larsen, L., Le Foll, C., Dunn-Meynell, A. A., & Levin, B. E. (2016). IL-6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic nucleus neurons. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 311(4), 764–770. https://doi.org/10.1152/ajpregu.00258.2016
Abstract
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Abstract
Rats selectively bred to develop diet-induced obesity (DIO) have an early onset reduction in the sensitivity of their ventromedial hypothalamic nucleus (VMN) neurons to leptin as compared to diet-resistant (DR) rats. This reduced sensitivity includes decreased leptin receptor (Lepr-b) mRNA expression, leptin receptor binding, leptin-induced phosphorylation of STAT3 (pSTAT3) and impaired leptin excitation (LepE) of VMN neurons. When administered exogenously, the pancreatic peptide, amylin, acts synergistically to reduce food intake and
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- Dunn-Meynell, Ambrose A
- Levin, Barry E
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Citations
Larsen, L., Le Foll, C., Dunn-Meynell, A. A., & Levin, B. E. (2016). IL-6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic nucleus neurons. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 311(4), 764–770. https://doi.org/10.1152/ajpregu.00258.2016
