Publication: Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial
Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial
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Chen, R. Y., Via, L. E., Dodd, L. E., Walzl, G., Malherbe, S. T., Loxton, A. G., Dawson, R., Wilkinson, R. J., Thienemann, F., Tameris, M., Diacon, A. H., Liu, X., & et al. (2017). Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial. Gates Open Research, 1:9. https://doi.org/10.12688/gatesopenres.12750.1
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Background: By the early 1980s, tuberculosis treatment was shortened from 24 to 6 months, maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have failed, with 4-month arms consistently having relapse rates of 15-20%. One trial shortened treatment only among those without baseline cavity on chest x-ray and whose month 2 sputum culture converted to negative. The 4-month arm relapse rate decreased to 7% but was still significantly worse than the 6-month arm (1.6%, P<0.01). We hypothesize that PET/CT charac
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- Chen, Ray Y
- Via, Laura E
- Dodd, Lori E
- Walzl, Gerhard
- Malherbe, Stephanus T
- Loxton, André G
- Dawson, Rodney
- Wilkinson, Robert J
- Thienemann, Friedrich
- Tameris, Michele
- Diacon, Andreas H
- Liu, Xin
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Chen, R. Y., Via, L. E., Dodd, L. E., Walzl, G., Malherbe, S. T., Loxton, A. G., Dawson, R., Wilkinson, R. J., Thienemann, F., Tameris, M., Diacon, A. H., Liu, X., & et al. (2017). Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial. Gates Open Research, 1:9. https://doi.org/10.12688/gatesopenres.12750.1
