Publication: Chromosomal changes characterize head and neck cancer with poor prognosis
Chromosomal changes characterize head and neck cancer with poor prognosis
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Bauer, V. L., Braselmann, H., Henke, M., Mattern, D., Walch, A., Unger, K., Baudis, M., Lassmann, S., Huber, R., Wienberg, J., Werner, M., & Zitzelsberger, H. F. (2008). Chromosomal changes characterize head and neck cancer with poor prognosis. Journal of Molecular Medicine, 86(12), 1353–1365. https://doi.org/10.1007/s00109-008-0397-0
Abstract
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Abstract
It is well established that genetic alterations may be associated to prognosis in tumor patients. This study investigates chromosomal changes that predict the clinical outcome of head and neck squamous cell carcinoma (HNSCC) and correlate to characteristic clinicopathological parameters. We applied comparative genomic hybridization (CGH) to tissue samples from 117 HNSCC patients scheduled for radiotherapy. Genomic aberrations occurring in more than five patients were studied for impact on locoregional progression (LRP)-free survival.
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- Bauer, V L
- Braselmann, H
- Henke, M
- Mattern, D
- Walch, A
- Unger, K
- Lassmann, S
- Huber, R
- Wienberg, J
- Werner, M
- Zitzelsberger, H F
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Bauer, V. L., Braselmann, H., Henke, M., Mattern, D., Walch, A., Unger, K., Baudis, M., Lassmann, S., Huber, R., Wienberg, J., Werner, M., & Zitzelsberger, H. F. (2008). Chromosomal changes characterize head and neck cancer with poor prognosis. Journal of Molecular Medicine, 86(12), 1353–1365. https://doi.org/10.1007/s00109-008-0397-0
