Distinct Expression Patterns of Cxcl12 in Mesenchymal Stem Cell Niches of Intact and Injured Rodent Teeth

Pagella, Pierfrancesco; Nombela-Arrieta, César; Mitsiadis, Thimios A

doi:10.3390/ijms22063024

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Pagella, P., Nombela-Arrieta, C., & Mitsiadis, T. A. (2021). Distinct Expression Patterns of Cxcl12 in Mesenchymal Stem Cell Niches of Intact and Injured Rodent Teeth. International Journal of Molecular Sciences, 22(6), 3024. https://doi.org/10.3390/ijms22063024

Abstract

Specific stem cell populations within dental mesenchymal tissues guarantee tooth homeostasis and regeneration throughout life. The decision between renewal and differentiation of stem cells is greatly influenced by interactions with stromal cells and extracellular matrix molecules that form the tissue specific stem cell niches. The Cxcl12 chemokine is a general marker of stromal cells and plays fundamental roles in the maintenance, mobilization and migration of stem cells. The aim of this study was to exploit Cxcl12-GFP transgenic mic