Publication: The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk
The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk
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Pastor-Arroyo, E.-M., Gehring, N., Krudewig, C., Costantino, S., Bettoni, C., Knöpfel, T., Sabrautzki, S., Lorenz-Depiereux, B., Pastor, J., Strom, T. M., Hrabě de Angelis, M., Camici, G. G., Paneni, F., Wagner, C. A., & Rubio-Aliaga, I. (2018). The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk. Kidney International, 94(1), 49–59. https://doi.org/10.1016/j.kint.2018.02.017
Abstract
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Abstract
High circulating fibroblast growth factor 23 (FGF23) levels are probably a major risk factor for cardiovascular disease in chronic kidney disease. FGF23 interacts with the receptor FGFR4 in cardiomyocytes inducing left ventricular hypertrophy. Moreover, in the liver FGF23 via FGFR4 increases the risk of inflammation which is also found in chronic kidney disease. In contrast, X-linked hypophosphatemia is characterized by high FGF23 circulating levels due to loss of function mutations of the phosphate-regulating gene with homologies to
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- Pastor-Arroyo, Eva-Maria
- Gehring, Nicole
- Krudewig, Christiane
- Costantino, Sarah
- Bettoni, Carla
- Knöpfel, Thomas
- Sabrautzki, Sibylle
- Lorenz-Depiereux, Bettina
- Pastor, Johanne
- Strom, Tim M
- Hrabě de Angelis, Martin
- Camici, Giovanni G
- Paneni, Francesco
- Wagner, Carsten A
- Rubio-Aliaga, Isabel
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Pastor-Arroyo, E.-M., Gehring, N., Krudewig, C., Costantino, S., Bettoni, C., Knöpfel, T., Sabrautzki, S., Lorenz-Depiereux, B., Pastor, J., Strom, T. M., Hrabě de Angelis, M., Camici, G. G., Paneni, F., Wagner, C. A., & Rubio-Aliaga, I. (2018). The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk. Kidney International, 94(1), 49–59. https://doi.org/10.1016/j.kint.2018.02.017
