Publication: Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments
Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments
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Ashcroft, P., Manz, M. G., & Bonhoeffer, S. (2017). Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments. PLoS Computational Biology, 13, e1005803. https://doi.org/10.1371/journal.pcbi.1005803
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Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. Experimental findings have suggested that they exist in a dynamic equilibrium, continuously migrating between these two compartments. Here we construct an individual-based mathematical model of this process, which is parametrised using existing empirical findings from mice. This approach allows us to quantify the amount of migration between the bone marrow niches and the peripheral blood. We u
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- Ashcroft, Peter
- Manz, Markus G
- Bonhoeffer, Sebastian
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Ashcroft, P., Manz, M. G., & Bonhoeffer, S. (2017). Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments. PLoS Computational Biology, 13, e1005803. https://doi.org/10.1371/journal.pcbi.1005803
