Publication: An Important Role of VEGF-C in Promoting Lymphedema Development
An Important Role of VEGF-C in Promoting Lymphedema Development
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Gousopoulos, E., Proulx, S. T., Bachmann, S. B., Dieterich, L. C., Scholl, J., Karaman, S., Bianchi, R., & Detmar, M. (2017). An Important Role of VEGF-C in Promoting Lymphedema Development. Journal of Investigative Dermatology, 137, 1995–2004. https://doi.org/10.1016/j.jid.2017.04.033
Abstract
Abstract
Abstract
Secondary lymphedema is a common complication after cancer treatment, but the pathomechanisms underlying the disease remain unclear. Using a mouse tail lymphedema model, we found an increase in local and systemic levels of the lymphangiogenic factor vascular endothelial growth factor (VEGF)-C and identified CD68$^{+}$ macrophages as a cellular source. Surprisingly, overexpression of VEGF-C in a transgenic mouse model led to aggravation of lymphedema with increased immune cell infiltration and vascular leakage compared with wild-type l
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Creators (Authors)
- Gousopoulos, Epameinondas
- Proulx, Steven T
- Bachmann, Samia B
- Dieterich, Lothar C
- Scholl, Jeannette
- Karaman, Sinem
- Bianchi, Roberta
- Detmar, Michael
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Citations
Gousopoulos, E., Proulx, S. T., Bachmann, S. B., Dieterich, L. C., Scholl, J., Karaman, S., Bianchi, R., & Detmar, M. (2017). An Important Role of VEGF-C in Promoting Lymphedema Development. Journal of Investigative Dermatology, 137, 1995–2004. https://doi.org/10.1016/j.jid.2017.04.033
