Publication: Macitentan attenuates cardiovascular remodelling in infant rats with chronic lung disease
Macitentan attenuates cardiovascular remodelling in infant rats with chronic lung disease
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Baumann, P., Greco, F., Wiegert, S., Wellmann, S., Pellegrini, G., & Cannizzaro, V. (2022). Macitentan attenuates cardiovascular remodelling in infant rats with chronic lung disease. Journal of Translational Medicine, 20(1), 77. https://doi.org/10.1186/s12967-022-03281-2
Abstract
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Abstract
Background: Cardiovascular impairment contributes to increased mortality in preterm infants with chronic lung disease. Macitentan, an endothelin-1 receptor antagonist, has the potential to attenuate pulmonary and cardiovascular remodelling. Methods: In a prospective randomized placebo-controlled intervention trial, Sprague–Dawley rats were exposed to 0.21 or 1.0 fraction of inspired oxygen (FiO2) for 19 postnatal days. Rats were treated via gavage with placebo or macitentan from days of life 5 to 19. Alveoli, pulmonary vessels, α-smoo
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Creators (Authors)
- Baumann, Philipp
- Greco, Francesco
- Wiegert, Susanne
- Wellmann, Sven
- Pellegrini, Giovanni
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Baumann, P., Greco, F., Wiegert, S., Wellmann, S., Pellegrini, G., & Cannizzaro, V. (2022). Macitentan attenuates cardiovascular remodelling in infant rats with chronic lung disease. Journal of Translational Medicine, 20(1), 77. https://doi.org/10.1186/s12967-022-03281-2
