Effects of trilostane on urinary catecholamines and their metabolites in dogs with hypercortisolism

Sieber-Ruckstuhl, Nadja S; Salesov, Elena; Quante, S; Riond, Barbara; Rentsch, K; Hofmann-Lehmann, Regina; Reusch, Claudia E; Boretti, Felicitas

doi:10.1186/s12917-017-1187-0

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Sieber-Ruckstuhl, N. S., Salesov, E., Quante, S., Riond, B., Rentsch, K., Hofmann-Lehmann, R., Reusch, C. E., & Boretti, F. (2017). Effects of trilostane on urinary catecholamines and their metabolites in dogs with hypercortisolism. BMC Veterinary Research, 13(1), 279. https://doi.org/10.1186/s12917-017-1187-0

Abstract

BACKGROUND: Glucocorticoids influence the synthesis and metabolism of catecholamines (epinephrine and norepinephrine) and metanephrines (metanephrine and normetanephrine). The aim of this study was to measure urinary catecholamines and metanephrines in dogs with hypercortisolism before and during trilostane therapy. Urine samples were collected during initial work up and during therapy with trilostane in 14 dogs with hypercortisolism and in 25 healthy dogs. Epinephrine, norepinephrine, metanephrine and normetanephrine were measured us