Multimodal assessment shows misalignment of structural and functional thalamocortical connectivity in children and adolescents born very preterm

Wehrle, Flavia M; Lustenberger, Caroline; Buchmann, Andreas; Latal, Beatrice; Hagmann, Cornelia Franziska; O'Gorman, Ruth L; Huber, Reto

doi:10.5167/uzh-186947

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Wehrle, F. M., Lustenberger, C., Buchmann, A., Latal, B., Hagmann, C. F., O’Gorman, R. L., & Huber, R. (2020). Multimodal assessment shows misalignment of structural and functional thalamocortical connectivity in children and adolescents born very preterm. NeuroImage, 215, 116779. https://doi.org/10.1016/j.neuroimage.2020.116779

Abstract

Thalamocortical connections are altered following very preterm birth but it is unknown whether structural and functional alterations are linked and how they contribute to neurodevelopmental deficits. We used a multimodal approach in 27 very preterm and 35 term-born children and adolescents aged 10 to 16 years: Structural thalamocortical connectivity was quantified with two measures derived from probabilistic tractography of diffusion tensor data, namely the volume of thalamic segments with cortical connections and mean fractional anis