Publication: Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats
Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats
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Krupkova, O., Sekiguchi, M., Klasen, J., Hausmann, O., Konno, S.-I., Ferguson, S. J., & Wuertz, K. (2014). Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats. European Cells and Materials (ECM), 28, 372–386. https://doi.org/10.22203/eCM.v028a26
Abstract
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Abstract
Intervertebral disc (IVD) disease, which is characterised by age-related changes in the adult disc, is the most common cause of disc failure and low back pain. The purpose of this study was to analyse the potential of the biologically active polyphenol epigallocatechin 3-gallate (EGCG) for the treatment of painful IVD disease by identifying and explaining its anti-inflammatory and anti-catabolic activity. Human IVD cells were isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D.
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- Krupkova, Olga
- Sekiguchi, Miho
- Klasen, J
- Hausmann, Oliver
- Ferguson, S J
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Krupkova, O., Sekiguchi, M., Klasen, J., Hausmann, O., Konno, S.-I., Ferguson, S. J., & Wuertz, K. (2014). Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats. European Cells and Materials (ECM), 28, 372–386. https://doi.org/10.22203/eCM.v028a26
