Publication: MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease
MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease
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Banerjee, S., Oneda, B., Yap, L. M., Jewell, D. P., Matters, G. L., Fitzpatrick, L. R., Seibold, F., Sterchi, E. E., Ahmad, T., Lottaz, D., & Bond, J. S. (2009). MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Mucosal Immunology, 2, 220–231. https://doi.org/10.1038/mi.2009.3
Abstract
Abstract
Abstract
The MEP1A gene, located on human chromosome 6p (mouse chromosome 17) in a susceptibility region for inflammatory bowel disease (IBD), encodes the alpha-subunit of metalloproteinase meprin A, which is expressed in the intestinal epithelium. This study shows a genetic association of MEP1A with IBD in a cohort of ulcerative colitis (UC) patients. There were four single-nucleotide polymorphisms in the coding region (P=0.0012-0.04), and one in the 3'-untranslated region (P=2 x 10(-7)) that displayed associations with UC. Moreover, meprin-a
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Creators (Authors)
- Banerjee, S
- Oneda, Beatrice
- Jewell, D P
- Matters, G L
- Fitzpatrick, L R
- Seibold, F
- Sterchi, E E
- Ahmad, T
- Lottaz, D
- Bond, J S
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Banerjee, S., Oneda, B., Yap, L. M., Jewell, D. P., Matters, G. L., Fitzpatrick, L. R., Seibold, F., Sterchi, E. E., Ahmad, T., Lottaz, D., & Bond, J. S. (2009). MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Mucosal Immunology, 2, 220–231. https://doi.org/10.1038/mi.2009.3
