Angiopoietin expression in ovine corpora lutea during the luteal phase: Effects of nutrition, arginine and follicle stimulating hormone

Gram, Aykut; Redmer, Dale A; Kowalewski, Mariusz P; Dorsam, Sheri T; Valkov, Veselina; Warang, Prajakta; Reyaz, Arshi; Bass, Casie S; Kaminski, Samantha L; Grazul-Bilska, Anna T

doi:10.1016/j.ygcen.2018.09.003

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Gram, A., Redmer, D. A., Kowalewski, M. P., Dorsam, S. T., Valkov, V., Warang, P., Reyaz, A., Bass, C. S., Kaminski, S. L., & Grazul-Bilska, A. T. (2018). Angiopoietin expression in ovine corpora lutea during the luteal phase: Effects of nutrition, arginine and follicle stimulating hormone. General and Comparative Endocrinology, 269, 131–140. https://doi.org/10.1016/j.ygcen.2018.09.003

Abstract

The aim of this study was to evaluate angiopoietin (ANGPT) 1 and 2, and tyrosine-protein kinase receptor 2 (TIE2) expression in the corpora lutea (CL) of FSH-treated, or non-treated sheep administered arginine (Arg) or vehicle (saline, Sal), and fed a control (C), excess (O) or restricted (U) diet. Ewes from each dietary group were treated with Arg or Sal (experiment 1), and with FSH (experiment 2). Luteal tissues were collected at the early-, mid- and/or late-luteal phases of the estrous cycle. Protein and mRNA expression was determi