Publication: Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood
Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood
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Buchmann, A. F., Holz, N., Boecker, R., Blomeyer, D., Rietschel, M., Witt, S. H., Schmidt, M. H., Esser, G., Banaschewski, T., Brandeis, D., Zimmermann, U. S., & Laucht, M. (2014). Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood. European Neuropsychopharmacology, 24(6), 837–845. https://doi.org/10.1016/j.euroneuro.2013.12.001
Abstract
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Abstract
Recent research suggests an important role of FKBP5, a glucocorticoid receptor regulating co-chaperone, in the development of stress-related diseases such as depression and anxiety disorders. The present study aimed to replicate and extend previous evidence indicating that FKBP5 polymorphisms moderate hypothalamus-pituitary-adrenal (HPA) function by examining whether FKBP5 rs1360780 genotype and different measures of childhood adversity interact to predict stress-induced cortisol secretion. At age 19 years, 195 young adults (90 males,
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Creators (Authors)
- Buchmann, Arlette F
- Holz, Nathalie
- Boecker, Regina
- Blomeyer, Dorothea
- Rietschel, Marcella
- Witt, Stephanie H
- Schmidt, Martin H
- Esser, Günter
- Banaschewski, Tobias
- Brandeis, Daniel
- Zimmermann, Ulrich S
- Laucht, Manfred
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Citations
Buchmann, A. F., Holz, N., Boecker, R., Blomeyer, D., Rietschel, M., Witt, S. H., Schmidt, M. H., Esser, G., Banaschewski, T., Brandeis, D., Zimmermann, U. S., & Laucht, M. (2014). Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood. European Neuropsychopharmacology, 24(6), 837–845. https://doi.org/10.1016/j.euroneuro.2013.12.001
