Time‐course of sodium transport along the nephron in nephrotic syndrome: the role of potassium

Dizin, Eva; Olivier, Valérie; Maire, Charline; Komarynets, Olga; Sassi, Ali; Roth, Isabelle; Loffing, Johannes; de Seigneux, Sophie; Maillard, Marc; Rutkowski, Joseph M; Edwards, Aurélie; Feraille, Eric

doi:10.1096/fj.201901345r

Citations

Citation copied

Dizin, E., Olivier, V., Maire, C., Komarynets, O., Sassi, A., Roth, I., Loffing, J., de Seigneux, S., Maillard, M., Rutkowski, J. M., Edwards, A., & Feraille, E. (2020). Time‐course of sodium transport along the nephron in nephrotic syndrome: the role of potassium. FASEB Journal, 34(2), 2408–2424. https://doi.org/10.1096/fj.201901345r

Abstract

The mechanism of sodium retention and its location in kidney tubules may vary with time in nephrotic syndrome (NS). We studied the mechanisms of sodium retention in transgenic POD-ATTAC mice, which display an inducible podocyte-specific apoptosis. At day 2 after the induction of NS, the increased abundance of NHE3 and phosphorylated NCC in nephrotic mice compared with controls suggest that early sodium retention occurs mainly in the proximal and distal tubules. At day 3, the abundance of NHE3 normalized, phosp