Publication: Fronto-Striatal Glutamate in Autism Spectrum Disorder and Obsessive Compulsive Disorder
Fronto-Striatal Glutamate in Autism Spectrum Disorder and Obsessive Compulsive Disorder
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Naaijen, J., Zwiers, M. P., Amiri, H., Williams, S. C. R., Durston, S., Oranje, B., Brandeis, D., Boecker-Schlier, R., Ruf, M., Wolf, I., Banaschewski, T., Glennon, J. C., Franke, B., Buitelaar, J. K., & Lythgoe, D. J. (2017). Fronto-Striatal Glutamate in Autism Spectrum Disorder and Obsessive Compulsive Disorder. Neuropsychopharmacology, 42, 2456–2465. https://doi.org/10.1038/npp.2016.260
Abstract
Abstract
Abstract
Autism spectrum disorders (ASDs) and obsessive compulsive disorder (OCD) are often comorbid with the overlap based on compulsive behaviors. Although previous studies suggest glutamatergic deficits in fronto-striatal brain areas in both disorders, this is the first study to directly compare the glutamate concentrations across the two disorders with those in healthy control participants using both categorical and dimensional approaches. In the current multi-center study (four centers), we used proton magnetic resonance spectroscopy in 5
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Creators (Authors)
- Naaijen, Jilly
- Zwiers, Marcel P
- Amiri, Houshang
- Williams, Steven C R
- Durston, Sarah
- Oranje, Bob
- Brandeis, Daniel
- Boecker-Schlier, Regina
- Ruf, Matthias
- Wolf, Isabella
- Banaschewski, Tobias
- Glennon, Jeffrey C
- Franke, Barbara
- Buitelaar, Jan K
- Lythgoe, David J
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Citations
Naaijen, J., Zwiers, M. P., Amiri, H., Williams, S. C. R., Durston, S., Oranje, B., Brandeis, D., Boecker-Schlier, R., Ruf, M., Wolf, I., Banaschewski, T., Glennon, J. C., Franke, B., Buitelaar, J. K., & Lythgoe, D. J. (2017). Fronto-Striatal Glutamate in Autism Spectrum Disorder and Obsessive Compulsive Disorder. Neuropsychopharmacology, 42, 2456–2465. https://doi.org/10.1038/npp.2016.260
