Publication: Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction
Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction
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Ganley, R. P., Werder, K., Wildner, H., & Zeilhofer, H. U. (2021). Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction. Molecular Pain, 17, 17448069211037888. https://doi.org/10.1177/17448069211037887
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Background: The locus coeruleus (LC) is the principal source of noradrenaline (NA) in the central nervous system. Projection neurons in the ventral portion of the LC project to the spinal cord and are considered the main source of spinal NA. To understand the precise physiology of this pathway, it is important to have tools that allow specific genetic access to these descending projections. AAV2retro serotype vectors are a potential tool to transduce these neurons via their axon terminals in the spinal cord, and thereby limit the expr
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- Ganley, Robert P
- Werder, Kira
- Wildner, Hendrik
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Ganley, R. P., Werder, K., Wildner, H., & Zeilhofer, H. U. (2021). Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction. Molecular Pain, 17, 17448069211037888. https://doi.org/10.1177/17448069211037887
