Publication: Transcription factor c-Myb: novel prognostic factor in osteosarcoma
Transcription factor c-Myb: novel prognostic factor in osteosarcoma
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Říhová, K., Dúcka, M., Zambo, I. S., Vymětalová, L., Šrámek, M., Trčka, F., Verner, J., Drápela, S., Fedr, R., Suchánková, T., Pavlatovská, B., Ondroušková, E., Kubelková, I., Zapletalová, D., Tuček, Š., Múdry, P., Krákorová, D. A., Knopfová, L., Šmarda, J., … Beneš, P. (2022). Transcription factor c-Myb: novel prognostic factor in osteosarcoma. Clinical & Experimental Metastasis, 39(2), 375–390. https://doi.org/10.1007/s10585-021-10145-4
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The transcription factor c-Myb is an oncoprotein promoting cell proliferation and survival when aberrantly activated/expressed, thus contributing to malignant transformation. Overexpression of c-Myb has been found in leukemias, breast, colon and adenoid cystic carcinoma. Recent studies revealed its expression also in osteosarcoma cell lines and suggested its functional importance during bone development. However, the relevance of c-Myb in control of osteosarcoma progression remains unknown. A retrospective clinical study was carried o
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Říhová, K., Dúcka, M., Zambo, I. S., Vymětalová, L., Šrámek, M., Trčka, F., Verner, J., Drápela, S., Fedr, R., Suchánková, T., Pavlatovská, B., Ondroušková, E., Kubelková, I., Zapletalová, D., Tuček, Š., Múdry, P., Krákorová, D. A., Knopfová, L., Šmarda, J., … Beneš, P. (2022). Transcription factor c-Myb: novel prognostic factor in osteosarcoma. Clinical & Experimental Metastasis, 39(2), 375–390. https://doi.org/10.1007/s10585-021-10145-4