Publication: IFNs modify the proteome of legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid
IFNs modify the proteome of legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid
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Naujoks, J., Tabeling, C., Dill, B. D., Hoffmann, C., Brown, A. S., Kunze, M., Kempa, S., Peter, A., Mollenkopf, H.-J., Dorhoi, A., Kershaw, O., Gruber, A. D., Sander, L. E., Witzenrath, M., Herold, S., Nerlich, A., Hocke, A. C., van Driel, I., Suttorp, N., … Opitz, B. (2016). IFNs modify the proteome of legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid. PLoS Pathogens, 12, e1005408. https://doi.org/10.1371/journal.ppat.1005408
Abstract
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Macrophages can be niches for bacterial pathogens or antibacterial effector cells depending on the pathogen and signals from the immune system. Here we show that type I and II IFNs are master regulators of gene expression during Legionella pneumophila infection, and activators of an alveolar macrophage-intrinsic immune response that restricts bacterial growth during pneumonia. Quantitative mass spectrometry revealed that both IFNs substantially modify Legionella-containing vacuoles, and comparative analyses reveal distinct subsets of
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- Naujoks, Jan
- Tabeling, Christoph
- Dill, Brian D
- Hoffmann, Christine
- Brown, Andrew S
- Kunze, Mareike
- Kempa, Stefan
- Peter, Andrea
- Mollenkopf, Hans-Joachim
- Dorhoi, Anca
- Kershaw, Olivia
- Gruber, Achim D
- Sander, Leif E
- Witzenrath, Martin
- Herold, Susanne
- Nerlich, Andreas
- Hocke, Andreas C
- van Driel, Ian
- Suttorp, Norbert
- Bedoui, Sammy
- Hilbi, Hubert
- Trost, Matthias
- Opitz, Bastian
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Naujoks, J., Tabeling, C., Dill, B. D., Hoffmann, C., Brown, A. S., Kunze, M., Kempa, S., Peter, A., Mollenkopf, H.-J., Dorhoi, A., Kershaw, O., Gruber, A. D., Sander, L. E., Witzenrath, M., Herold, S., Nerlich, A., Hocke, A. C., van Driel, I., Suttorp, N., … Opitz, B. (2016). IFNs modify the proteome of legionella-containing vacuoles and restrict infection via IRG1-derived itaconic acid. PLoS Pathogens, 12, e1005408. https://doi.org/10.1371/journal.ppat.1005408
