Publication: N-methyl pyrrolidone as a potent bone morphogenetic protein enhancer for bone tissue regeneration
N-methyl pyrrolidone as a potent bone morphogenetic protein enhancer for bone tissue regeneration
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San Miguel, B., Ghayor, C., Ehrbar, M., Jung, R. E., Zwahlen, R. A., Hortschansky, P., Schmoeckel, H. G., & Weber, F. E. (2009). N-methyl pyrrolidone as a potent bone morphogenetic protein enhancer for bone tissue regeneration. Tissue Engineering. Part A, 15, 2955–2963. https://doi.org/10.1089/ten.TEA.2009.0009
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In medicine N-methylpyrrolidone (NMP) has a long track record as constituent in FDA approved medical devices and thus can be considered as safe and biological inactive small chemical. In the present study we report on the newly discovered pharmaceutical properties of NMP as it enhances bone regeneration in a rabbit calvarial defect model in vivo. At the cellular level, the pharmaceutical effect of NMP was confirmed, in particular, in combination with BMP-2, as NMP increased early and late markers for maturation of preosteoblasts and h
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- San Miguel, Blanca
- Ghayor, Chafik
- Jung, Ronald E
- Zwahlen, Roger A
- Hortschansky, Peter
- Schmoeckel, Hugo G
- Weber, Franz E
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San Miguel, B., Ghayor, C., Ehrbar, M., Jung, R. E., Zwahlen, R. A., Hortschansky, P., Schmoeckel, H. G., & Weber, F. E. (2009). N-methyl pyrrolidone as a potent bone morphogenetic protein enhancer for bone tissue regeneration. Tissue Engineering. Part A, 15, 2955–2963. https://doi.org/10.1089/ten.TEA.2009.0009
