Publication: Limits to robustness and reproducibility in the demarcation of operational taxonomic units
Limits to robustness and reproducibility in the demarcation of operational taxonomic units
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Schmidt, T. S. B., Matias Rodrigues, J. F., & von Mering, C. (2015). Limits to robustness and reproducibility in the demarcation of operational taxonomic units. Environmental Microbiology, 17(5), 1689–1706. https://doi.org/10.1111/1462-2920.12610
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The demarcation of operational taxonomic units (OTUs) from complex sequence data sets is a key step in contemporary studies of microbial ecology. However, as biologically motivated 'optimal' OTU-binning algorithms remain elusive, many conceptually distinct approaches continue to be used. Using a global data set of 887 870 bacterial 16S rRNA gene sequences, we objectively quantified biases introduced by several widely employed sequence clustering algorithms. We found that OTU-binning methods often provided surprisingly non-equivalent p
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- Schmidt, Thomas S B
- Matias Rodrigues, João F
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SNF 31003A_135688
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Schmidt, T. S. B., Matias Rodrigues, J. F., & von Mering, C. (2015). Limits to robustness and reproducibility in the demarcation of operational taxonomic units. Environmental Microbiology, 17(5), 1689–1706. https://doi.org/10.1111/1462-2920.12610