Management of Pediatric Mild Traumatic Brain Injury Patients: S100b, Glial Fibrillary Acidic Protein, and Heart Fatty-Acid-Binding Protein Promising Biomarkers

Chiollaz, Anne-Cécile; Pouillard, Virginie; Spigariol, Fabian; Romano, Fabrizio; Seiler, Michelle; Ritter Schenk, Céline; Korff, Christian; Habre, Céline; Maréchal, Fabienne; Wyss, Verena; Gruaz, Lyssia; Lamana-Vallverdu, Marcel; Chocano, Elvira; Sempere Bordes, Lluis; Luaces-Cubells, Carlos; Méndez-Hernández, María; Alonso Cadenas, José Antonio; Carpio Linde, María José; de la Torre Sanchez, Paula; Montaner, Joan

doi:10.1089/neur.2024.0027

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Chiollaz, A.-C., Pouillard, V., Spigariol, F., Romano, F., Seiler, M., Ritter Schenk, C., Korff, C., Habre, C., Maréchal, F., Wyss, V., Gruaz, L., Lamana-Vallverdu, M., Chocano, E., Sempere Bordes, L., Luaces-Cubells, C., Méndez-Hernández, M., Alonso Cadenas, J. A., Carpio Linde, M. J., de la Torre Sanchez, P., … Sanchez, J.-C. (2024). Management of Pediatric Mild Traumatic Brain Injury Patients: S100b, Glial Fibrillary Acidic Protein, and Heart Fatty-Acid-Binding Protein Promising Biomarkers. Neurotrauma Reports, 5(1), 529–539. https://doi.org/10.1089/neur.2024.0027

Abstract

Children are highly vulnerable to mild traumatic brain injury (mTBI). Blood biomarkers can help in their management. This study evaluated the performances of biomarkers, in discriminating between children with mTBI who had intracranial injuries (ICIs) on computed tomography (CT+) and (1) patients without ICI (CT−) or (2) both CT− and in-hospital-observation without CT patients. The aim was to rule out the need of unnecessary CT scans and decrease the length of stay in observation in the emergency department (ED). Newborns to teenagers