Publication: The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice
The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice
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Boeddrich, A., Babila, J. T., Wiglenda, T., Diez, L., Jacob, M., Nietfeld, W., Huska, M. R., Haenig, C., Groenke, N., Buntru, A., Blanc, E., Meier, J. C., Vannoni, E., Erck, C., Friedrich, B., Martens, H., Neuendorf, N., Schnoegl, S., Wolfer, D. P., … Wanker, E. E. (2019). The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice. Cell Chemical Biology, 26(1), 109-120.e7. https://doi.org/10.1016/j.chembiol.2018.10.013
Abstract
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Abstract
Self-propagating amyloid-β (Aβ) aggregates or seeds possibly drive pathogenesis of Alzheimer's disease (AD). Small molecules targeting such structures might act therapeutically in vivo. Here, a fluorescence polarization assay was established that enables the detection of compound effects on both seeded and spontaneous Aβ42 aggregation. In a focused screen of anti-amyloid compounds, we identified Disperse Orange 1 (DO1) ([4-((4-nitrophenyl)diazenyl)-N-phenylaniline]), a small molecule that potently delays both seeded and non-seeded Aβ4
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- Boeddrich, Annett
- Babila, Julius T
- Wiglenda, Thomas
- Diez, Lisa
- Jacob, Manuela
- Nietfeld, Wilfried
- Huska, Matthew R
- Haenig, Christian
- Groenke, Nicole
- Buntru, Alexander
- Blanc, Eric
- Meier, Jochen C
- Vannoni, Elisabetta
- Erck, Christian
- Friedrich, Beate
- Martens, Henrik
- Neuendorf, Nancy
- Schnoegl, Sigrid
- Wolfer, David P
- Loos, Maarten
- Beule, Dieter
- Andrade-Navarro, Miguel A
- Wanker, Erich E
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Boeddrich, A., Babila, J. T., Wiglenda, T., Diez, L., Jacob, M., Nietfeld, W., Huska, M. R., Haenig, C., Groenke, N., Buntru, A., Blanc, E., Meier, J. C., Vannoni, E., Erck, C., Friedrich, B., Martens, H., Neuendorf, N., Schnoegl, S., Wolfer, D. P., … Wanker, E. E. (2019). The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice. Cell Chemical Biology, 26(1), 109-120.e7. https://doi.org/10.1016/j.chembiol.2018.10.013
