Expanded skeletal stem and progenitor cells promote and participate in induced bone regeneration at subcritical BMP-2 dose

Papageorgiou, Panagiota; Vallmajo-Martin, Queralt; Kisielow, Malgorzata; Sancho-Puchades, Alejandro; Kleiner, Esther; Ehrbar, Martin

doi:10.1016/j.biomaterials.2019.119278

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Papageorgiou, P., Vallmajo-Martin, Q., Kisielow, M., Sancho-Puchades, A., Kleiner, E., & Ehrbar, M. (2019). Expanded skeletal stem and progenitor cells promote and participate in induced bone regeneration at subcritical BMP-2 dose. Biomaterials, 217, 119278. https://doi.org/10.1016/j.biomaterials.2019.119278

Abstract

The regeneration of large bone defects remains an unsolved clinical problem, which could benefit from recent findings on the biology of skeletal stem and progenitor cells. The elucidation of conditions to specifically control their dynamic and function will likely enable the development of novel treatment strategies. In this study, we aimed at dissecting the role of osteogenic cues and skeletal stem (SSC) and progenitor cell (BCSP) recruitment during biomimetic hydrogel-assisted bone regeneration. To do so, we employed a biomimetic sy