IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation

Amorim, Ana; De Feo, Donatella; Friebel, Ekaterina; Ingelfinger, Florian; Anderfuhren, Cyrill Dimitri; Krishnarajah, Sinduya; Andreadou, Myrto; Welsh, Christina A; Liu, Zhaoyuan; Ginhoux, Florent; Greter, Melanie; Becher, Burkhard

doi:10.1038/s41590-021-01117-7

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Amorim, A., De Feo, D., Friebel, E., Ingelfinger, F., Anderfuhren, C. D., Krishnarajah, S., Andreadou, M., Welsh, C. A., Liu, Z., Ginhoux, F., Greter, M., & Becher, B. (2022). IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation. Nature Immunology, 23(2), 217–228. https://doi.org/10.1038/s41590-021-01117-7

Abstract

During inflammation, Ly6Chi monocytes are rapidly mobilized from the bone marrow (BM) and are recruited into inflamed tissues, where they undergo monocyte-to-phagocyte transition (MTPT). The in vivo developmental trajectories of the MTPT and the contribution of individual cytokines to this process remain unclear. Here, we used a murine model of neuroinflammation to investigate how granulocyte-macrophage colony-stimulating factor (GM-CSF) and interferon-γ (IFNγ), two type 1 cytokines, controlled MTPT. Using genetic fate mapping, gene t