Publication: Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Once Daily Empagliflozin 25 mg for the Treatment of Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass
Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Once Daily Empagliflozin 25 mg for the Treatment of Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass
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Ferreira, A., Schönenberger, K. A., Potoczna, N., Vogt, A., Gerber, P. A., Zehetner, J., Giachino, D., Nett, P., Gawinecka, J., Cossu, L., Fuster, D. G., Dalla Man, C., Facchinetti, A., Melmer, A., Nakas, C. T., Hepprich, M., Donath, M. Y., Herzig, D., & Bally, L. (2023). Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Once Daily Empagliflozin 25 mg for the Treatment of Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass. Diabetes Technology & Therapeutics, 25(7), 467–475. https://doi.org/10.1089/dia.2023.0036
Abstract
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Aims: To investigate the effect of empagliflozin on glucose dynamics in individuals suffering from postbariatric hypoglycemia (PBH) after Roux-en-Y gastric bypass (RYGB).
Methods: Twenty-two adults with PBH after RYGB were randomized to empagliflozin 25 mg or placebo once daily over 20 days in a randomized, double-blind, placebo-controlled, crossover trial. The primary efficacy outcome was the amplitude of plasma glucose excursion (peak to nadir) during a mixed-meal tolerance test (MMTT). Outcomes of the outpatient period were assess
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Creators (Authors)
- Ferreira, Antonio
- Schönenberger, Katja A
- Potoczna, Natascha
- Vogt, Andreas
- Gerber, Philipp A
- Zehetner, Jörg
- Giachino, Daniel
- Nett, Philipp
- Gawinecka, Joanna
- Cossu, Luca
- Fuster, Daniel G
- Dalla Man, Chiara
- Facchinetti, Andrea
- Melmer, Andreas
- Nakas, Christos T
- Hepprich, Matthias
- Donath, Marc Y
- Herzig, David
- Bally, Lia
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Citations
Ferreira, A., Schönenberger, K. A., Potoczna, N., Vogt, A., Gerber, P. A., Zehetner, J., Giachino, D., Nett, P., Gawinecka, J., Cossu, L., Fuster, D. G., Dalla Man, C., Facchinetti, A., Melmer, A., Nakas, C. T., Hepprich, M., Donath, M. Y., Herzig, D., & Bally, L. (2023). Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Once Daily Empagliflozin 25 mg for the Treatment of Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass. Diabetes Technology & Therapeutics, 25(7), 467–475. https://doi.org/10.1089/dia.2023.0036
