Transcorneal electrical stimulation shows neuroprotective effects in retinas of light-exposed rats

Schatz, A; Arango-Gonzalez, B; Fischer, D; Enderle, H; Bolz, S; Röck, T; Naycheva, L; Grimm, C; Messias, A; Zrenner, E; Bartz-Schmidt, K U; Willmann, G; Gekeler, F

doi:10.5167/uzh-64494

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Schatz, A., Arango-Gonzalez, B., Fischer, D., Enderle, H., Bolz, S., Röck, T., Naycheva, L., Grimm, C., Messias, A., Zrenner, E., Bartz-Schmidt, K. U., Willmann, G., & Gekeler, F. (2012). Transcorneal electrical stimulation shows neuroprotective effects in retinas of light-exposed rats. Investigative Ophthalmology & Visual Science, 53(9), 5552–5561. https://doi.org/10.1167/iovs.12-10037

Abstract

Purpose. To examine the effects of transcorneal electrical stimulation (TES) on retinal degeneration of light-exposed rats. Methods. Thirty-three Sprague Dawley albino rats were divided into three groups: STIM (n = 15) received 60 minutes of TES, whereas SHAM (n = 15) received identical sham stimulation 2 hours before exposure to bright light with 16,000 lux; healthy animals (n = 3) served as controls for histology. At baseline and weekly for 3 consecutive weeks, dark- and light-adapted electroretinography was used to assess retinal f