Publication: Assessment of the Role of Endothelial mTORC2 in FGF2-induced Angiogenesis in vivo
Assessment of the Role of Endothelial mTORC2 in FGF2-induced Angiogenesis in vivo
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Georgiopoulou, S. (2015). Assessment of the Role of Endothelial mTORC2 in FGF2-induced Angiogenesis in vivo. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-114847
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Angiogenesis is a process where new capillaries are formed from pre-existing ones. It involves endothelial cell activation, extracellular matrix degradation, endothelial cell proliferation and migration and fusion with neighboring sprouts. Stabilization and lumen formation of the new capillary are the last steps of sprouting angiogenesis. Sprouting angiogenesis is one the most prominent mechanism of tumor vascularization and is a growth factor-driven process with FGF2 and VEGF being the key regulators. The mTOR signaling pathway is a
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Georgiopoulou, S. (2015). Assessment of the Role of Endothelial mTORC2 in FGF2-induced Angiogenesis in vivo. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-114847