Publication: Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis
Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis
Date
Date
Date
Citations
Recknagel, P., Gonnert, F. A., Westermann, M., Lambeck, S., Lupp, A., Rudiger, A., Dyson, A., Carré, J. E., Kortgen, A., Krafft, C., Popp, J., Sponholz, C., Fuhrmann, V., Hilger, I., Claus, R. A., Riedemann, N. C., Wetzker, R., Singer, M., Trauner, M., & Bauer, M. (2012). Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Medicine, 9(11), e1001338. https://doi.org/10.1371/journal.pmed.1001338
Abstract
Abstract
Abstract
BACKGROUND: Hepatic dysfunction and jaundice are traditionally viewed as late features of sepsis and portend poor outcomes. We hypothesized that changes in liver function occur early in the onset of sepsis, yet pass undetected by standard laboratory tests. METHODS AND FINDINGS: In a long-term rat model of faecal peritonitis, biotransformation and hepatobiliary transport were impaired, depending on subsequent disease severity, as early as 6 h after peritoneal contamination. Phosphatidylinositol-3-kinase (PI3K) signalling was simultaneo
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Recknagel, Peter
- Gonnert, Falk A
- Westermann, Martin
- Lambeck, Sandro
- Lupp, Amelie
- Rudiger, Alain
- Dyson, Alex
- Carré, Jane E
- Kortgen, Andreas
- Krafft, Christoph
- Popp, Jürgen
- Sponholz, Christoph
- Fuhrmann, Valentin
- Hilger, Ingrid
- Claus, Ralf A
- Riedemann, Niels C
- Wetzker, Reinhard
- Singer, Mervyn
- Trauner, Michael
- Bauer, Michael
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
Series Name
Series Name
Series Name
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Recknagel, P., Gonnert, F. A., Westermann, M., Lambeck, S., Lupp, A., Rudiger, A., Dyson, A., Carré, J. E., Kortgen, A., Krafft, C., Popp, J., Sponholz, C., Fuhrmann, V., Hilger, I., Claus, R. A., Riedemann, N. C., Wetzker, R., Singer, M., Trauner, M., & Bauer, M. (2012). Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Medicine, 9(11), e1001338. https://doi.org/10.1371/journal.pmed.1001338
