Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis

Locke, Warwick J; Zotenko, Elena; Stirzaker, Clare; Robinson, Mark D; Hinshelwood, Rebecca A; Stone, Andrew; Reddel, Roger R; Huschtscha, Lily I; Clark, Susan J

doi:10.1186/s13148-015-0086-0

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Locke, W. J., Zotenko, E., Stirzaker, C., Robinson, M. D., Hinshelwood, R. A., Stone, A., Reddel, R. R., Huschtscha, L. I., & Clark, S. J. (2015). Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis. Clinical Epigenetics, 7(1), 52. https://doi.org/10.1186/s13148-015-0086-0

Abstract

BACKGROUND: Dysregulation of the epigenome is a common event in malignancy; however, deciphering the earliest cancer-associated epigenetic events remains a challenge. Cancer epigenome studies to date have primarily utilised cancer cell lines or clinical samples, where it is difficult to identify the initial epigenetic lesions from those that occur over time. Here, we analysed the epigenome of human mammary epithelial cells (HMEC) and a matched variant cell population (vHMEC) that have spontaneously escaped senescence and undergone par