Publication: Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach
Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach
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Sieber, S., Grendelmeier, S. M., Harris, L. A., Mitchell, D. A., & Gademann, K. (2020). Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach. Journal of Natural Products, 83(2), 438–446. https://doi.org/10.1021/acs.jnatprod.9b00986
Abstract
Abstract
Abstract
The toxicity of the cyanobacterium Microcystis aeruginosa EAWAG 127a was evaluated against the sensitive grazer Thamnocephalus platyurus, and the extract possessed strong activity. To investigate the compounds responsible for cytotoxicity, a series of peptides from this cyanobacterium were studied using a combined genomic and molecular networking approach. The results led to the isolation, structure elucidation, and biological evaluation of microviridin 1777, which represents the most potent chymotrypsin inhibitor characterized from t
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- Grendelmeier, Simone M
- Harris, Lonnie A
- Mitchell, Douglas A
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SNSF
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200021_182043
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Mechanism-Based Design, Synthesis, Biological Evaluation, and Delivery of Next-Generation Antibiotics
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Sieber, S., Grendelmeier, S. M., Harris, L. A., Mitchell, D. A., & Gademann, K. (2020). Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach. Journal of Natural Products, 83(2), 438–446. https://doi.org/10.1021/acs.jnatprod.9b00986
